By boosting innate immunity can eradicate aggressive prostate cancer in mice

Drug activates neutrophils instead of T cells, leading to cancer clearance

University of Chicago Medical Center

Cabozantinib, an FDA-approved drug for patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils -- the first-responders of the immune system -- to infiltrate the tumor. This novel approach, utilizing the innate immune system, produced near-complete clearance of invasive prostate cancers within 48 to 72 hours.

Journal Reference:

Akash Patnaik, Kenneth D. Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P. Gehring, Katja Helenius, Brian M. Olson, Athalia R. Pyzer, Lily C. Wang, Olivier Elemento, Jesse Novak, Thomas B. Thornley, John M. Asara, Laleh Montaser, Joshua J. Timmons, Todd M. Morgan, Yugang Wang, Elena Levantini, John G. Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M. Rosenblatt, David E. Avigan, Huihui Ye, Jeffrey M. Karp, Sabina Signoretti, Steven P. Balk, Lewis C. Cantley. Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Anti-Tumor Innate Immunity. Cancer Discovery, 2017; CD-16-0778 DOI: 10.1158/2159-8290.CD-16-0778

Comments

How healthy is genetically modified soybean oil?

University of California-Riverside Soybean oil accounts for more than 90 percent of all the seed oil production in the United States. Genetically modified soybean oil, made from seeds of GM soybean plants, was recently introduced into the food supply on the premise that it is healthier than conventional soybean oil. But is that premise true? Just barely, say scientists. Researchers at the University of California, Riverside have tested a genetically-modified (GM) soybean oil used in restaurants and found that while it induces less obesity and insulin resistance than conventional soybean oil, its effects on diabetes and fatty liver are similar to those of conventional soybean oil.

HEALTH BENEFITS OF CHEWING RAW GARLIC

HEALTH BENEFITS OF CHEWING RAW GARLIC You might not make a lot of new friends if you chew on garlic, a plant used for centuries as both a pungent flavoring and a medicine. A member of the onion family, garlic contains a powerful sulfur compound called allicin, which also lends it a distinctive – and to many people, unpleasant – smell.Garlic not only makes food delicious, it may also have a number of health benefits. The allicin in garlic exhibits strong antioxidant activity – the ability to fight harmful free radicals in the body – which has led scientists to study its health-promoting properties. OFFERS AN ANTI-INFLAMMATORY EFFECT If you suffer from an inflammatory condition, it may help to consume raw garlic. A study published in "Food and Chemical Toxicology" in August 2013 found that garlic had an anti-inflammatory effect, with raw garlic exhibiting a stronger effect than garlic that had been heated. The levels of a compound called allicin were great...

Babies are born to dance, new research shows

University of York The findings, based on the study of infants aged between five months and two years old, suggest that babies may be born with a predisposition to move rhythmically in response to music. The research was conducted by Dr Marcel Zentner, from the University of York's Department of Psychology, and Dr Tuomas Eerola, from the Finnish Centre of Excellence in Interdisciplinary Music Research at the University of Jyvaskyla.

Eagle Eye Science

Search This Blog